MM Chemotherapeutic and Associated Regimens

MM Chemotherapeutic and Associated Regimens

Compiled by Chris Hollyer

Any additions, suggestions or corrections please email Chris Hollyer at chris@mmsupport.net

1D09C3 Anti-MHC (major histocompatibility complex) class II monoclonal antibody.

17-AAG Koss 953 in stage 1 trial DFCI

2CDA Cladribine, (antimetabolite) trade name Leustatin

2ME2 2-Methoxyestradiol (synthetic estrogen metabolite) in trial at Dana Faber.

5-FU 5-Fluorouracil (Adrucil, Fluorouracil Roche) older MM chemo

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ACE-011 Phase I trial of a bone regenerative therapeutic.

ABCM Adriamycin, BCNU (Carmustine), Cyclophosphamide, Melphalan

ACTIMID Imunomodulatory drug (IMiDs) CC4047 Celgene Corp. Thalidomide analog.

AP Alkeran (Melphalan), Prednisone (Same as MP)

AMD-3100 CXCR-4 blocker in trial for stem cell mobilisation therapy

As2O3 Arsenic Trioxide. (Sometimes given with Vit. C & Melphalan) aka, MAC

Atiprimod IL-6 inhibitor. Phase I/IIa trial. DFCI & MDA.

AVN 944 Phase I trial of a novel small molecule inhibitor of Inosine Monophosphate Dehydrogenase (IMPDH)

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BAM Velcade, ascorbic acid (Vitamin C) Melphalan

BEAC BCNU, cytarabine, cyclophosphamide

BCE Busulphan, Cyclophosphamide, Etoposide, Conditioning regimen for SCT

BCNU Carmustine

BCP BCNU, Cyclophosphamide, Prednisone

BD Biaxin, Dexamethasone

BDCMD BCNU, Doxorubicin, Cyclophosphamide, Melphalan, Dexamethasone.

BDD BCNU (Carmustine) Doxorubicin, Dexamethasone

BEAM BCNU, Etoposide (VP16), Cytarabine, Melphalan

BIAXIN Clarithromycin

BiRD Biaxin, Revlimid, Dexamethasone

BT Biaxin, Thalidomide

BLT-D Biaxin (clarithromycin), Low-Dose Thalidomide, Dexamethasone

BLT-DM Biaxin, Low-Dose Thalidomide, Dexamethasone, low dose Melphalan

BLT-P Biaxin, Low-Dose Thalidomide, Prednisone

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CAD Cyclophosphamide, Adriamycin, Dexamethasone

CAMPATH Monoclonal Anti-CD52 Antibody in trial at Mayo Clinic Rochester MN

CARMEL Carmustine (BCNU), Melphalan in trial at Cornell

CBP Cyclophosphamide, Biaxin, Prednisone

CC-5013/V CC-5013 , Velcade .

CELECOXIB Celebrex for Newly dx MGUS Temporarily withheld.

CHIR-12.12 A Phase 1 Trial of Anti-CD40 Monoclonal Antibody

CHIR 258 Tyrosine kinase inhibitor stage I trial

CHOP Cyclophosphamide, Adriamycin, Vincristine, Prednisone

CID Cyclophosphamide, Idarubicin, Dexamethasone

Clarithromycin Biaxin

CNT O328 Monoclonal antibody phase I trial

CP Cyclophosphamide, Prednisone

CTD Cyclophosphamide, Thalidomide, Dexamethasone

Cytoxan Cyclophosphamide

C-weekly Cyclophosphamide weekly

CDEP Dexamethasone, Cyclophosphamide, Etoposide, Cisplatin

C-O6 O6-benzylguanine plus Carmustine sometimes called O6-BCNU

C-VAD Cyclophosphamide, Vincristine, Adriamycin, Dexamethasone

C-VAMP VAMP plus C (Cyclophosphamide) -weekly

C-WAP Cyclophosphamide weekly plus alternate day Prednison

CYCLOPAMINE Hedgehog pathway antagonist Pre-Clinical

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Decadron Dexamethasone

DATA Dexamethasone, Ascorbic Acid, Thalidomide, Arsenic Trioxide

DCAB Dexamethasone, Cyclophosphamide, Adriamycin, BCNU

DCEP Dexamethasone, Cyclophospamide, Etoposide and Cisplatin

DCEP-T Dexamethasone, Cyclophosphamide, Etoposide, Cisplatin, Thalidomide

DdT Doxil, Dexamethasone, Thalidomide

DHAP Cisplatin, HD Cytosine Arabinoside, Dexamethasone

DPACE Dexamethasone, Cisplatin, Adriamycin, Cyclophosphamide, Etoposide.

DT-PACE Dexamethasone, Thalidomide, Cisplatin, Adriamycin, Cyclophosphamide, Etoposide.

DVD Doxil (Doxorubicin), Vincristine, Dexamethasone

DVD-R Doxil, Vincristine, Dexamethasone, Revlimid

DVD-T Doxil, Vincristine, Dexamethasone, Thal (used in Cleveland Clinic trial)

DVG Daunorubicin - Vinorelbine (Navelbine) and Gemcitabine

DVT-PACE Dexamethasone, Velcade, Thalidomide, Cisplatin, Adriamycin, Cyclophosphamide, Etoposide

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EDAP Etoposide, Dexamethasone, Cytosine Arabinoside, Cisplatin

EPOCH Etoposide, Prednisone, Vincristine, Cyclophosphamide, Adriamycin

ESHAP Etopside, Cisplatin, Methyl-prednisolone Cytarabine

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FAC Fluorouracil ("5-FU"), Adriamycin, and Cyclophosphamide

FLUPHENAZINE serotonin antagonist PHASE I TRIAL

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GDT Genasense (oblimersen sodium, G3139), dexamethasone and thalidomide

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HMR1275 Flavopiridol - in multi cancer stage I trial DFCI

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ICE Ifosfamide, Carboplantin, Etoposide

ICM idarubicin, cyclophosphamide and melphalan (study in Germany abandoned due to high mortality rate)

IPI-504 Heat Shock Protein 90 (Hsp90) inhibitor - phase I trial

IVE Ifosphamide, Vinblastine, Etoposide

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KOS-953 17-AAG heat shock protein (HSP90) inhibitor. Trialing at DFCI

Also being trialled in Arizona (Ph I) w. Velcade.

KRX 0401 Perifosine. Multi centre phase II trials Jan Ô06

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LD-VTD Low dose Velcade, Thalidomide and Dexamethasone

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M2 Vincristine, BCNU, Melphalan, Cyclophosphamide, Prednisone

M80 Oral Melphalan 80 mg/m2 , Dexamethasone 40 mg/m2

MAC Melphalan, Arsenic Trioxide (AsO3), Vitamin C

MAC-P Melphalan, Arsenic Trioxide, Vitamin C, Prednisone

MCBP Melphalan, Cyclophosphamide, BCNU, Prednisone

MGd Motexafin Gadolinium - in trial at Northwestern.

MOCCA Methyl prednisolone, Vincristine, Cyclophosphamide, CCNU, Melphalan

MOD Mitoxantrone (Novatrone), Vincristine, Dexamethasone

MP Melphalan, Prednisone (Most widely used treatment for MM)

MPT Melphalan, Prednisone, Thalidomide

MV Melphalan, Velcade

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NOP Mitoxantrone (Novatrone), Vincristine, Prednisone

NVP-ADW742 selective kinase inhibitor Pre-Clinical

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PAD PS341 (Velcade), Adriamycin, Dexamethasone

PCAB Prednisone, Cyclophosphamide, Adriamycin, BCNU

PR-171 Proteolix - proreasome inhibitor, ph I/II trials

PVC Prednisone, Velcade, Cyclophosphamide

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QUADRAMET Samarium Sm-153 lexidronam injection - Cytogen Corp.

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REVLIMID Imunomodulatory drug (IMiD) CC5013 Celgene Corp. (Thalidomide analog.)

RITUXAN Monoclonal Antibody targeting CD20+ B cells

RD Revlimid, Dexamethasone

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SCIO-469 Phase 1 trial @ St Vincent's.  A new class of treatment that inhibits p38 MAP kinase.

SSG Sodium Stibogluconate phase I trial

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THALIDOMIDE Thalomid - immunomodulatory agent (IMiD) Celgene Corp.

TC Thalidomide, Celecoxib (Celebrex) phase II trial

TCD Thalidomide, Cyclophosphamide, Dexamethasone

TCID Thalidomide, Cyclophosphamide, Idarubicin, Dexamethasone

TCP Thalidomide, Cyclophosphamide, Prednisone

THaDD Thalidomide, Dexamethasone, Pegylated Liposomal Doxorubicin

TL Thalidomide, Leukine Stage II trial, Weill/Cornell

TMB Thalidomide, Medrol, Biaxin

TP Thalidomide, Prednisone

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VAC Velcade, Arsenic Trioxide, Ascorbic acid, Phase I/II trial

VAD Vincristine, Adriamycin (now sometimes Doxorubicin), Dexamethasone (Second most widely used MM chemo regime)

VAD-PQ VAD, plus alternate day Prednisone (10-50mg), Quinine

VAM Velcade, Ascorbic Acid (Vitamin C), Melphalan

VAMP Vincristine, Adriamycin, Methyl Prednisone

C-VAMP VAMP plus C (Cyclophosphamide) -weekly

VBAD Vincristine, BCNU, Adriamycin, Dexamethasone

VBAM-Dex Vincristine, BCNU, Adriamycin, Melphalan, Dexamethasone

VBAP Vincristine, BCNU, Adriamycin, Prednisone

VBAPP Vincristine, BCNU, Adriamycin, Procarbazine, Prednisone

VBAP/Z-DEX Vincristine, Carmustine, Doxorubicin, Prednisone, Idarubicin (Zavedos), Dexamethasone.

VBMCP Vincristine, BCNU, melphalan, cyclophosphamide, prednisone

VED Vincristine, Epirubicin, Dexamethasone.

VED-T Velcade, Epirubicin, Dexamethasone, Thalidomide.

VELCADE Bortezomib (formerly MLN341, LDP-341, and PS-341) Millenium Pharmaceuticals.

VELSAM Velcade, Quadramet - phase I trial

VD Velcade, Dexamethasone

VDC Velcade, Doxil/Caelix (pegylated liposomal doxorubicin).

VDd Velcade, Doxorubicin, Dexamethasone. Phase II trial

VDT Velcade, Doxil, Thalidomide

VD-TAP Velcade, Dexamethasone, Thalidomide, Doxil, Cisplatin.

VF Velcade, Flavopiridol. Stage I trial.

VL-MTD Velcade, Low Dose Melphalan, Thalidomide, Dexamethasone

VBMCP Vincristine, BCNU, Melphalan, Cyclophosphamide, Prednisone (M2 protocol)

VDT-PACE Velcade, Thalidomide, Dexamethasone, Cisplatin, Adriamycin, Cyclophosphamide, Etoposide. ACRC Total Therapy III regimen - UART 203-33 clinical trial.

VMCP Vincristine, Melphalan, Cyclophosphamide, Prednisone

VMCPA Vincristine, Melphalan, Cyclophosphamide, Prednisone, Adriamycin

VMCPP Vincristine, Melphalan, Cyclophosphamide, Procarbazine, Prednisone

VMCP/ VBAP Vincristine, Melphalan, Cyclophosphamide, Prednisone, alternating with Vincristine, Carmustine, Doxorubicin, Prednisone

V-MP Velcade, Melphalan, Prednisone.

VND Vincristine, Mitoxantrone, Dexamethasone

VR Velcade, Revlimid stage I trial DFCI

VT Velcade, Tubacin in vitro trial at Harvard Medical School

VTC Velcade, Trisenox, Vitamin C

VTD Velcade, Thalidomide, Dexamethasone

V V Velcade, Vorinostat (Suberoylanilide Hydroxamic Acid) Ph I trial.

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Z-DEX Idarubicin, Dexamethasone.

Copyright © 2005 Chris Hollyer. All Rights Reserved.